Doripenem is an antibiotic that fights serious infections caused by bacteria. Usually administered as an injection, it is also used to treat severe infections of the stomach, bladder, or kidneys. Doripenem was approved by the United States Food and Drug Administration on October 12, 2007, to be sold under the tradename Doribax.

The family of antibiotics to which doripenem belongs may cause severe allergic reactions, especially in people with history of multiple allergies.

Seizures have also been reported in some patients taking doripenem, especially among people with a previous history of seizures, or who are taking medications to control seizures. People who have a prior history of seizures or use of the drug sodium valproate for seizures should not be administered with doripenem.

Doripenem has only been associated with seizures in people who were at risk for seizures such as a history of epilepsy, are taking medications to control seizures or have head injuries or other damage to brain tissue and not in people who do not have conditions that predispose them to seizures.

Anemia, renal impairment, and renal failure have been observed more frequently in patients treated with doripenem than comparators. Doripenem has not been associated with anemia due to rupture of red cells.

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Via Johns Hopkins poc-IT Center/DrugLib